Enzyme Genomics Project: Prelude

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 General Statistics 



Note: artifactual orphans = orphans which actually have sequences associated with the enzymatic activity

 

Species Distribution of Validated Orphans



Rescuability Ranking Distribution



Example Rescuable Orphans



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Artifactual orphan activities  

Click here for a downloadable list of artifactual orphan E.C. numbers, i.e., cases where a protein sequence can be found in a Swiss-Prot or trEMBL entry (Microsoft Excel format, read-only).

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Validated orphan activities  

A downloadable list of all VALIDATED orphan EC numbers can be downloaded by clicking here (Microsoft Excel format, read-only).

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Species Overview

• At least 54 species represented in 65 orphans
• 43% prokaryotic
• 57% eukaryotic
• 54% of species have a completely sequenced genome available now, or shortly

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Species Distribution for Prokaryotic Orphans

Note: includes artefactual orphans



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Species Distribution for Eukaryotic Orphans



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Rescuability Ranking Distribution

• High: 2/16
• Good: 4/16
• Medium: 1/16
• Marginal: 9/16

Examples of rescuable orphans:



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Ranking Factors Used In Assessing “Rescuability” of Orphans

• Availability of sequenced genome
  • .. Or partial protein sequence
• Recent enzyme characterization
• Availability of at least two of …
  • Mr (especially from high fidelity technique)
  • pI
  • Protease digest(s)
  • Number of cysteines
  • Amino acid content

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