Enzyme Genomics Survey

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General Statistics

Enzyme Genomics Results - Descriptive Stats

Note: artifactual orphans = orphans which actually have sequences associated with the enzymatic activity

Species Distribution of Validated Orphans

Enzyme Genomics Species Overview of Validated Orphans

Rescuability Ranking Distribution

Enzyme Genomics Orphan Rescuability Ranking

Example Rescuable Orphans

Enzyme Genomics Examples of Rescuable Orphans

Artifactual orphan activities

Click here for a downloadable list of artifactual orphan E.C. numbers, i.e., cases where a protein sequence can be found in a Swiss-Prot or trEMBL entry (Microsoft Excel format, read-only).

Validated orphan activities

A downloadable list of all VALIDATED orphan EC numbers can be downloaded by clicking here (Microsoft Excel format, read-only).

Species Overview

At least 54 species represented in 65 orphans
43% prokaryotic
57% eukaryotic
54% of species have a completely sequenced genome available now, or shortly

Species Distribution for Prokaryotic Orphans

Note: includes artefactual orphans

Enzyme Genomics Prokaryotic Species Orphan Distribution

Species Distribution for Eukaryotic Orphans

Enzyme Genomics Eukaryotic Species Orphan Distribution

Rescuability Ranking Distribution

High: 2/16
Good: 4/16
Medium: 1/16
Marginal: 9/16

Examples of rescuable orphans:

Enzyme Genomics Rescuable Orphans

Ranking Factors Used In Assessing “Rescuability” of Orphans

Availability of sequenced genome
- .. Or partial protein sequence
Recent enzyme characterization
Availability of at least two of …
- Mr (especially from high fidelity technique)
- pI
- Protease digest(s)
- Number of cysteines
- Amino acid content