Pathway Tools is now available for Linux x86_64 machines. Please note that these executables will only run on a Linux x86_64 machine. Please pay attention to the sizes of the Linux x86_64 executables that are listed in the table below. We recommend that the machine on which you run these images have an amount of RAM of at least the executable size. The 64-bit Linux version with all three tiers requires more than 4GB of RAM memory and has a long startup time. We only recommend downloading this version if you are planning to do large-scale comparative analyses.
Also please note that none of the built-in PGDBs of any tier are editable. If editable PGDBs are needed, a distribution containing few tiers should be chosen, and the PGDBs to be edited should be downloaded from the Registry.

System Requirements

Operating System
Most of the testing of Pathway Tools on the following operating systems has been done for 32-bit versions.
- Linux on any AMD or Intel-based x86 system that uses a version 2.2 or higher kernel, OpenMotif (not LessTif), and glibc 2.1+
  Known to work on:
  - the Redhat family, including Fedora Core 3 and Fedora Core 4
  - Debian Linux, version 3.1, after ensuring the installation of OpenMotif. It works on Ubuntu-6.06 .
  Known Problems:
  - On Suse-8.2 on a x86_64 system, one user reported that restarting the WWW server mode of Pathway Tools by means of automated scripts never got to work. The problem does not seem to occur on Suse-8.1 .
- Microsoft Windows NT, 2000, XP, or later versions
- Solaris 8 (not tested on Solaris 9)
Hardware
- Processor: Minimum requirement = 1GHz
- Memory (RAM) recommended
  - Tier 1 (2 PGDBs, EcoCyc and MetaCyc): 768MB
  - Tier 1 + Tier 2 (around 15 PGDBs): 1GB
  - Tier 1 + Tier 2 + Tier 3 (around 260 PGDBs): (64-bit 3GHz CPU required), 8GB
  For a web server, larger RAM space may be necessary to accommodate a large number of connections. The swap space of your operating system should also be setup to accommodate your RAM space.
- Disk space: Minimum requirement ranges from 150MB (Tier 1 DBs EcoCyc and MetaCyc only) to 450MB (Tier 1 and Tier 2 DBs)